Before trying that, check your database for corruption:
- activate debug logging (not ‘verbose’!)
- quit Plex Server
- wait 1 minute
- start Plex Server
- wait 5 minutes
- fetch log files and attach them here
Or inspect them yourself. Take a look at the Plex Media Server.log file and seek for messages about database corrupt or malformed.
If you find these, you may have to repair your database.
Another thing to look at is whether your server has exceeded the number of folders it is able to monitor for changes: Linux Tips - #9 by ChuckPa