I've been having problems with the Plex server and remote connections on a new router, and no my Plex seems completely FUBAR. I deleted and installed a fresh Plex Media Server, started it up.... Plex reports the new service isn't up. When I look at the service, via the browser:
"You must be lost."
"This page doesn't exist."
This is using the pulldown menu Plex > Preferences....
I've never seen this before, and regardless of any remote access problems I've had I've always been able to access plex locally or on the local lan.