It has been determined that this setting is only beneficial to users with particularly big libraries.
A change by factor 10 is way too large. This buffer is per DB session, not globally per database. So making it too large can negatively impact performance if there are many concurrent DB sessions (i.e. clients accessing at the same time).
See if the use of this database repair script makes any difference for you: GitHub - ChuckPa/PlexDBRepair: Database repair utility for Plex Media Server databases
