My server after a format and clean install of Windows 10 Pro was no longer waking up when in sleep mode when opening a Plex client.
I finally tracked the culprit down. Under Power settings for Windows, go to the “Choose what the power buttons do” or whatever its called, on the left hand side. Click the “Change settings that are currently unavailable” link and some checkboxes appear. I unchecked “Turn on fast start up”.
I also made sure that the network adapter power settings allowed wake on activity and not just magic packet.
And now everything works great. When the server is asleep, starting up a Plex client or starting an RDP connect will wake it up! Fantastic!

