Clear "cache" folder, once or twice a month, is it safe?

Plex Media Server Desktops & Laptops
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2

Perfectly safe … I’ve been deleting this weekly via a cronjob for well over a year now (maybe over 2 years) …

sudo rm -rf /var/lib/plexmediaserver/Library/Application\ Support/Plex\ Media\ Server/Plug-in\ Support/Caches/*
sudo rm -rf /var/lib/plexmediaserver/Library/Application\ Support/Plex\ Media\ Server/Plug-in\ Support/Data/*
sudo rm -rf /var/lib/plexmediaserver/Library/Application\ Support/Plex\ Media\ Server/Plug-in\ Support/Metadata\ Combination/*
sudo rm -rf /var/lib/plexmediaserver/Library/Application\ Support/Plex\ Media\ Server/Cache/PhotoTranscoder/*

The Cache/PhotoTranscoder is the worst! It can grow unbounded if not controlled and managed outside of plex. See Cache/PhotoTranscoder Folder Size Sanity Check for details.