You can do that with some registry editing…
- Stop PMS
- Copy the PMS data folder (
C:\Users\<user>\AppData\Local\Plex Media Server\) to a new location (e.g.D:\Data\Plex Media Server\) - Open the registry editor and navigate to `HKEY_CURRENT_USER\Software\Plex, Inc.\Plex Media Server
- Find the entry
LocalAppDataPath– if it doesn’t exist… create it - Set the entry to the new target path (
D:\Data\Plex Media Server\based on the example above) - Save your changes to the Registry
- Restart the Plex Media Server
- After confirming Plex is using the new location you can delete the original Plex App-Data folder
Important: If you copy the data folder while Plex is still running, you can end up with a corrupted database… so make sure to shut down the Plex Media Server before starting this!!
https://support.plex.tv/articles/201105343-advanced-hidden-server-settings/
Edit: I just figured there’s already a more extensive description (incl. some pics) in the Tips & Tricks section: