What does this mean? Will you be using UNC paths instead?
Can’t you solve this by giving the media drives the exact same drive letters they currently have on your old server?
If you really have to change all the paths/adresses of your media files, you may want to look a this: [HowTo] Plex database modification - Moving media the right/wrong way - #10 by jelwell
Supplementary reading: [HowTo] An extended guide on how to move the Plex data folder on Windows