Plexamp rpi stuck

It’s working fine most of the time, but after a long pause I always see this error and have to restart the service, the song does not start, any idea ?

Feb 22 17:35:41 raspberrypi node[505]: debug: METRICS: Starting new track.
Feb 22 17:35:41 raspberrypi node[505]: error: [POWER] Error opening serial port! Error: Error: No such file or directory, cannot open /dev/ttyUSB0
Feb 22 17:35:41 raspberrypi node[505]: debug: METRICS: Sending event: playback:itemend to https://analytics.plex.tv
Feb 22 17:35:42 raspberrypi node[505]: debug: METRICS: Sending event: playback:itemstart to https://analytics.plex.tv

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