I’ve continued looking into this and it appears that a shared library link either being incorrect or missing is probably the issue based on what I read here (albeit for docker issue): Error on start - plexmediaserver (1.29.1.6260-420892357) - drmGetDevices2 - #43 by jesplex
The logs of my attempt to stop, repair, start here:
Starting plex via appcenter works reliably, and is the only method I can use to start it so perhaps some differences in the shell environment between logging in as qnap admin vs appcenter are to blame…