"We are unable to play this video, make sure the serves is running..." error message

Sounds very similar to this current issue: An error occurred while attempting to play this video. Please try restarting both the Plex Media Server and this app

Try some of the suggestions there such as disabling the new player and/or disabling passthrough.
New player works for me but passthrough causes a server issue even though its not actually a server issue as other players work fine.