AMD 4750G with FreeNAS

Plex doesn’t usually publish plans. But there’s a feature request open for AMD hardware encoding support.

[Feature Request] Add support for AMD's Video Core Next encoding

If you want a lower powered CPU that has embedded transcoding support, consider an Intel CPU with QuickSync.

https://support.plex.tv/articles/115002178853-using-hardware-accelerated-streaming/

I’m a TrueNAS user myself, but … if you want the best/easiest hardware acceleration support, you might consider Linux. Notes from others that have gotten hardware transcoding working on FreeNAS:

GitHub - kern2011/Freenas-Quicksync: How to guide for getting Intel Quicksync working on Freenas

Consider too the support for accelerated tone mapping:

https://support.plex.tv/articles/hdr-to-sdr-tone-mapping/

As you said, much of this may not be important if you don’t expect to use server-side transcoding. This will be dependent on your files, users, and playback devices.