@marekszulik Thank you for the response. Can your team also take a look at this issue?
This issue has been going on for months and I narrowed it down for content that is Dolby Vision and Dolby Atmos. Essentially after some time of viewing any media with both Dolby Vision and Atmos, the OSD becomes unresponsive, when trying to bring up the OSD while media is playing, the media also becomes unresponsive. The only way to mitigate was to force close the plex app and start it again. That only works for a little while and the problem appears again.
I did notice this happening more frequently after the memory leaks fixes from long time ago.