Supplemental:
This is my configuration
[chuck@lizum ~.2051]$ cat /etc/systemd/system/plexmediaserver.service.d/override.conf
[Service]
Environment="PLEX_MEDIA_SERVER_APPLICATION_SUPPORT_DIR=/usb/plex"
User=chuck
Group=chuck
[chuck@lizum ~.2052]$
/var/lib/plexmediaserver still exists, is owned by my username, but is empty.
/usb/plex is really a 2TB SSD now. No longer a HDD