Check your main Plex database file for damage:
- activate debug logging (not ‘verbose’!)
- quit Plex Server
- wait 1 minute
- start Plex Server
- wait 5 minutes
- fetch log files and attach them here
Or inspect them yourself. Take a look at the Plex Media Server.log file and seek for messages about database corrupt or malformed.
If you find these, you may have to repair your database.
