I’ve tried it and most things are working pretty good - a few graphics slowdowns etc as you expect with beta software.
Plex seems to be more affected than other apps so far though, some things play fine, others play the audio with no video. DVR seems completely broken as it just bails out of the screen.
The good news is playing it in safari as a workaround does work - so that’s something.
If it were easy I’d actually downgrade as I use Plex on my tablet quite a lot - however, I’ll just use the browser and wait.
Hope that helps someone.