Specifically the Bring "Plexamp to the foreground and focus search" hotkey. It is set by default as Shift+Control+Space, but this conflicts with some games, making it impossible to play them while Plexamp plays music in the background. Moreover, is there somewhere other settings like this can be changed? As far as I know the only changes that can be made are those that can be found by left-clicking the Plexamp icon in the tray (as well as disabling crossfade/normalization in a .json buried in AppData). Any help would be appreciated, have really been enjoying the app so far (especially for gapless playback).
Figured it out. Added some code to config.json from https://gist.github.com/elan/e3039d5e870356296f78249afc52d243
and modified it to new binding.