I’m running fresh install of Windows 10 on a Dell Optiplex 780 with 8 gig of RAM with an Intel® Core™ 2 Quad CPU. After installation, the program initially launched, but now nothing happens when I try to run it. I’ve tried installing in Safe mode and as the admin.
Do you see a Plex icon in the system tray?

This icon should have a context menu with an option to open the web app.
Alternatively you can open http://127.0.0.1:32400/web on the same machine – after you’ve finished the setup you can also use https://app.plex.tv/desktop.
The server itself doesn’t have a native/local user interface – it’ll run in the background and can be managed via the browser or some of the Plex clients.
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