Server Version#: 1.41.3.9232
Player Version#: v.1.105.1.257-3bc35ab9
In search within this forum and wider across the www, there are various threads about Plex Player audio being out of sync with the Apple HomePod speakers. I have recently acquired a HomePod Gen 2 and also experience the out of sync issue, this is approx 1-3 secs.
I have managed to determine that this sync issue is ONLY between the Plex-player Mac the the HomePod.
My Plex Server is a Mac mini 2018 i7 64GB ram, an external GPU and a couple of 4K/5K displays, the LG 40WP95C-W was the default audio until the HomePod arrived.
I have confirmed that there is no sync issue when using Plex on the iPad or the Apple TV 4K and sending to the HomePod.
Also there is no sync issue if using Plex Web in a browser on the same Mac mini as the Plex Server.
What looks to be required, is for the Plex player Mac to have the audio controls enabled in the UI and / or to be able to select an audio source other than the default of the desktop that the player is running on.
This would then allow the Plex Player Mac to send the audio directly and in sync.