I can only guess, but the Ryzen 4000 series APUs use the same VCN 2.0 core as the Radeon RX 5x00 series GPUs. Both GPUs (integrated and discrete) share this same common architectural piece which may be the common failure point. I would bet anything that Plex does not have a fully up-to-date and compliant VCN/VCE codebase meaning no proper support for these GPUs’ codec block.
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