I’m having the same exact issue. Server version up to date. Selecting ‘check for updates’ does open successfully in safari. But, when selecting ‘open Plex’ from server, it crashes with the message “a problem repeatedly occurred with 127.0.0.1:32400/web/index.html”.
I installed the desktop App for Mac and that works fine. Seems to only be when opening in safari.
Remote access from other devices also works fine.