Suddenly, can't open the Plex server on Mac

I’ve been using Plex server for at least 15 or more years. I have a large library. Suddenly, for no discernible reason, I can no longer open the Plex server. I get the message: “Can’t establish a connection to the server at 127.0.0.1:32400.” Everything else is working fine, including internet access. Would appreciate any help you can provide. I find this unusually depressing. Thanks.

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