There have been quite a few different TVs that would have the audio cut out right in the middle of them. Sometimes it is very close to commercial breaks while other times it can be in the middle. I have had terrible luck with comedy central shows, specifically, Key and Peele and South Park.
Southpark S17E06 - 720p, the audio cut right after the intro. We end up just pushing it from my Plex app on my phone or plex web to chromecast, which does not have the same audio cutting out issue. I am not sure if this issue has been addressed yet or if it is getting fixed, but currently that is the only bug I have been seeing in PlexConnect. If there is any anything I could provide to help find a fix, let me know.