Cannot playback any media (4294967283) Windows and (s1001) Web

Server Version#: Version 1.23.1.4528 (Windows)
Player Version#: Version 4.55.1 (Windows)

All of a sudden I am unable to play back any media.

May 17, 2021 22:50:58.199 [19068] Error — [Transcode] MDE: video has neither a video stream nor an audio stream
May 17, 2021 22:50:58.199 [19068] Error — [Transcode] MDE: video has neither a video stream nor an audio stream
May 17, 2021 22:50:58.199 [19068] Error — [Transcode] Streaming Resource: Cannot make a decision because either the file is unplayable or the client provided bad data
May 17, 2021 22:50:58.571 [18892] Error — [Transcode] MDE: video has neither a video stream nor an audio stream
May 17, 2021 22:50:58.571 [18892] Error — [Transcode] MDE: video has neither a video stream nor an audio stream
May 17, 2021 22:50:58.571 [18892] Error — [Transcode] Streaming Resource: Cannot make a decision because either the file is unplayable or the client provided bad data

I have tried:

Complete uninstall, including deleting all references to Plex, Inc. in the registry, program files (x86), and local profile, reboot, reinstall.

Both VLC and Emby play with no problems. All local hard drives on the server, no NAS or Cloud.

Rolling back to the previous server version fixed my issue.

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