Error issuing curl_easy_perform(handle):52

I’m seeing a lot of these errors in my logs:

May 20, 2017 12:21:49.744 [0x7fd3198b0700] ERROR - Error issuing curl_easy_perform(handle):52
May 20, 2017 12:21:49.744 [0x7fd3198b0700] WARN - HTTP error requesting GET http://192.168.0.68:8008/ssdp/device-desc.xml (0, No error) (Empty reply from server)
May 20, 2017 12:27:59.744 [0x7fd311da1700] ERROR - Error issuing curl_easy_perform(handle):52
May 20, 2017 12:27:59.744 [0x7fd311da1700] WARN - HTTP error requesting GET http://192.168.0.68:8008/ssdp/device-desc.xml (0, No error) (Empty reply from server)
May 20, 2017 12:29:59.780 [0x7fd311da1700] ERROR - Error issuing curl_easy_perform(handle): 52
May 20, 2017 12:29:59.781 [0x7fd311da1700] WARN - HTTP error requesting GET http://192.168.0.68:8008/ssdp/device-desc.xml (0, No error) (Empty reply from server)
May 20, 2017 12:32:19.745 [0x7fd3198b0700] ERROR - Error issuing curl_easy_perform(handle): 52
May 20, 2017 12:32:19.745 [0x7fd3198b0700] WARN - HTTP error requesting GET http://192.168.0.68:8008/ssdp/device-desc.xml (0, No error) (Empty reply from server)
May 20, 2017 12:40:39.746 [0x7fd311da1700] ERROR - Error issuing curl_easy_perform(handle): 52
May 20, 2017 12:40:39.746 [0x7fd311da1700] WARN - HTTP error requesting GET http://192.168.0.68:8008/ssdp/device-desc.xml (0, No error) (Empty reply from server)

The device at 192.168.0.68 is my Chromecast, which is plugged in, powered on and working but not currently casting from Plex (it’s showing images from Google’s screensaver).

Any ideas how to debug this?

If the affected device is always your chromecast, there is nothing you can or must do.
Not an error as such.

If however the affected host was plex.tv or some host on Amazon AWS, then it is most likely an issue with ‘jumbo frames’ or an incorrect MTU size setting on your NAS (too large for your internet connection).

LOL
How in the heck does one determine which it is??