I really hope that they fix this problem as it never use to be an issue.
For those of you who can’t save channel mappings once there is over around 360 channels:
Revert plex back to version 1.41.6.9685(this is the version that worked for me) let’s me save channel mappings for my 716 channels.
After setting up Live TV and all your channel mappings, then upgrade plex to latest version.
The channels still update and play, just can’t add any new channel mappings unless you revert back to the older version i listed above again. At least on the windows version. Npt sure if other OS versions have this issue or not.