This should cover everything you need to know about setting up PMS on a RPi. If the USB drive is NTFS make sure you have the NTFS 3g package installed on the pi.
Introduction
Plex supports Debian and Ubuntu based ARMv7 (armhf) and ARMv8 (arm64) distributions.
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Manage Expectations
Video transcoding is not recommended at all on ARMv7 and ARMv8 devices. For the best experience, always aim for Direct Play support on all of your devices.
OS Installation
It’s out of scope of …