No response from Plex Media Server !

Hello every one , I installed Plex on my window and Apple TV 3 recently, I added many plug in bundle to my channel but on both ( window and ATV ) I get this message “No response from Plex Media Server” and it can’t play the episods or … , I can see all channel logos and episode picture tile but I can’t play them ,
every time I entered to a channel to play I got this message on my PlexConnect.py (Python 27):
" request Timeout=20
HTTP error 500 : Internal server error "
I had this problem on window and Apple TV
I disabled my firewall but same error
I’m using window 7 (64X)

TNX

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