- Shut down Plex server, including the ‘Plex Update Service’
- uninstall Plex Server using the regular Windows Apps control panel
- download the latest beta of Plex Server and install it on drive C: (it will only occupy ~155 MB)
- remove the key
LocalAppDataPath
completely from the registry
If you later want to really save space on drive C:, follow this guide: Moving Metadata on Windows - #3 by OttoKerner