The Plex Media Server database might be corrupted.
Pull the Plex server log files (Settings → Troubleshooting → Download Logs). See Reporting Issues with Plex Media Server.
In Plex Media Server.log look for statements such as:
Nov 18, 2020 14:00:13.540 [8432] ERROR - SQLITE3:0xbc9d53c5, 11, database corruption at line 85694 of [bf8c1b2b7a]
Nov 18, 2020 14:00:13.540 [8432] ERROR - SQLITE3:0xbc9d53c5, 11, statement aborts at 80: [select media_items.id as 'media_items_id', media_items.library_section_id as 'media_items_library_section_id', media_items.section_location_id as 'media_items_section_location_id', med
Nov 18, 2020 14:00:13.543 [8432] ERROR - Soci Exception handled: sqlite3_statement_backend::loadRS: database disk image is malformed
If the database is corrupted, see this article: