Same problem here. EAC3 no sound until I restart Plex server. Using new Plex windows client. Here’s some logs when I played and got no sound, before restarting.
Sep 25, 2019 00:08:37.119 [0x86ff0b40] ERROR - Error issuing curl_easy_perform(handle): 28
Sep 25, 2019 00:09:06.661 [0x7d3feb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:09:15.298 [0x7d3feb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:09:16.470 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:09:16.498 [0xb19fdb40] ERROR - Session 0xb2b1a63c terminated
Sep 25, 2019 00:09:16.590 [0x867efb40] WARN - SLOW QUERY: It took 230.000000 ms to retrieve 51 items.
Sep 25, 2019 00:09:32.446 [0x7bbfbb40] INFO - AutoUpdate: no updates available
Sep 25, 2019 00:09:54.100 [0x7cbfdb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:02.777 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:12.777 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:16.255 [0x7cbfdb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:21.730 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:22.403 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:25.984 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:34.652 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:10:34.786 [0x867efb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:12:03.746 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:12:11.950 [0xa41ffb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:12:21.952 [0xa41ffb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:12:45.169 [0xa41ffb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:12:47.759 [0x7bbfbb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:16:19.204 [0xa41ffb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:16:20.776 [0x7cbfdb40] ERROR - Unable to find client profile for device; platform=windows, platformVersion=7sp1, device=, model=standalone
Sep 25, 2019 00:16:20.784 [0xb19fdb40] ERROR - Session 0xa0eb769c terminated
<Media id="102252" duration="1574048" bitrate="3317" width="1280" height="720" aspectRatio="1.78" audioChannels="6" audioCodec="eac3" videoCodec="h264" videoResolution="720" container="mkv" videoFrameRate="24p" videoProfile="main">
<Part accessible="1" exists="1" id="105967" key="/library/parts/105967/1536933630/file.mkv" duration="1574048" file="x.mkv" size="652620296" container="mkv" videoProfile="main">
<Stream id="209362" streamType="1" default="1" codec="h264" index="0" bitrate="3317" bitDepth="8" chromaLocation="left" chromaSubsampling="4:2:0" frameRate="23.976" hasScalingMatrix="0" height="720" level="31" profile="main" refFrames="3" scanType="progressive" width="1280" displayTitle="720p (H.264)"/>
<Stream id="209363" streamType="2" selected="1" default="1" codec="eac3" index="1" channels="6" language="English" languageCode="eng" audioChannelLayout="5.1(side)" samplingRate="48000" displayTitle="English (EAC3 5.1)"/>
<Stream id="209364" streamType="3" codec="srt" index="2" language="English" languageCode="eng" displayTitle="English (SRT)"/>
<Stream id="209365" streamType="3" codec="srt" index="3" language="Suomi" languageCode="fin" displayTitle="Suomi (SRT)"/>
<Stream id="209366" streamType="3" codec="srt" index="4" language="Deutsch" languageCode="ger" displayTitle="Deutsch (SRT)"/>
<Stream id="209367" streamType="3" codec="srt" index="5" language="Norsk bokmål" languageCode="■■■" displayTitle="Norsk bokmål (SRT)"/>
<Stream id="209368" streamType="3" codec="srt" index="6" language="Svenska" languageCode="swe" displayTitle="Svenska (SRT)"/>
</Part></Media>