This is going to be wordy so anyone suffering same will understand everything I’ve tried.
So in my quest for a more power efficient Plex server, I recently setup an HP Elitebook as my new server. See this post: https://forums.plex.tv/discussion/278382/my-new-server-a-gasp-laptop#latest
A few days after copying all my existing media to the new drives, I was having issues with Plex telling me the media wasn’t available. Funny, I just watched part of that TV Series yesterday. I remote into the server and open explorer. To my dismay, half of my television series folders are not there and some that are, cannot be accessed. WUT? Digging deeper, a lot of my Movie folders have the same issue. 
My first assumption was i got a bad drive BUT my TV Series and my Movies are kept on separate drives. Is it possible I got two bad drives? Running chkdsk /f I see TONS of issues. Long story short, I fear one of several scenarios.
- I got two bad drives (unlikely)
- My Laptop has a USB issue
- There are problems with the external cases I am using
- I have a virus
Step 1. Boot off a pen drive, do a triple redundant virus/malware scan. CLEAN
Step 2. Connect my 4tb Seagate USB drive and run read/writes tests for 24hrs. CLEAN
Step 3. Change from MBR to GPT on external drives and start all over again.
So I hook the drives to the old server , wipe them and start fresh. Copy 12tb of media to the new drives again, move them to the laptop server.
Two days later… files vanishing and drive corruption again. 
The ThermalTake Max 5G hard drive cases I was using were not rated for 6tb drives but I had been reading people saying they had no issues using them. Not to take chances, I ordered a Noontec-TerraMaster D4-310 to hold my drives setup in a JBOD mode.
ONCE AGAIN, I hook the drives to the old server , wipe them copy 12tb of media to them and move them to the laptop server.
Three days later… yup, you guessed it. Going… going… GONE. Total drive corruption on both drives.
Doing some research, it SEEMS this MIGHT come down to the fact that my old server is a Windows 7 machine and the new one, Windows 10. There are threads about people suffering a similar plight when using a USB hard drive on both a Windows 7 machine and a Windows 10 machine.
Currently I have the media once again being transferred to the new drives. On the laptop server I’m going to try disabling all USB sleep/power saving modes, disable write caching and whatever other voodoo settings I can come up with. My fingers are crossed.

