I am also having this error on Google Chromecast with Google TV. I can not watch any video anymore and I can not stream live tv. Odd enough, I can play music fine. Videos was working fine up until last night, so Plex must have broken the app via an update or something. All other clients (web client, webOS, Android) are fine.
This is not acceptable to jam out an update that completely breaks the client. I want to watch a movie tonight, so please get this fixed pronto, Plex.