Many thanks for your help! (and sorry for my late reply)
Well, I tried nearly everything again… reinstalling plex, the Nvidia driver … no luck. But I think I found the culprit. The Quadro M2000 is only sitting in a tiny x4 slot and I think that’s why nearly everything fails. Could be luck transcoding works with the mobile app, who knows…
I´ll try it in a different system with a proper x16 slot and let you know!