As a software engineer myself, I don’t see how devs can solve this problem with just complaints in a forum thread.
Server setup, client setup (version, hardware, OS, AV setup, screen), video file specs are all a determining factor in this. Without a way to reproduce, there’s no hope this will ever get fixed.
I myself posted here when I noticed some sync issues on one TV show I own. It turns out the issue lied in the multiplexing of the mkv files. And none of my other movies/shows are affected.
In order to assert whether files or setup were to blame, I bought the Spears & Munsil UHD HDR Benchmark disc and ripped it to my Plex server. And it shows A/V in perfect sync.
PM me and I can share this file with you. If you see A/V sync issues on this file, then something is wrong in Plex or your setup and we can investigate from there. If there ano A/V sync issues, then the issue might be in the video files you are playing. Maybe try to share a sample and I can try on my setup to see how it goes.