Plex Media Server won't update or uninstall

FYI, C:\ProgramData is a hidden folder. You can make it visible in Windows Explorer by selecting the View tab then checking the box next to Hidden items.

Regarding your update issue, see the two items linked below. The first mentions using Microsoft’s Fix It tool and a procedure fixing Windows Update issues (which may also help Plex). The second mentions editing the Windows Registry and removing a specific key.

Windows: Errors trying to upgrade, install, or uninstall Plex Media Server