Plex server disappears once in a while. Reappears on restarting it

Server Version#: v1.42.2.10122

This has been happening for a month atleast. There are even times when you can play content on one device while other sees it as offline. Restarting Plex server immediately brings it back.

I use GitHub - AdguardTeam/AdGuardHome: Network-wide ads & trackers blocking DNS server at home where the Plex server is. Could that be blocking some traffic that can cause this ?