Some items to check:
Leave the VPN disconnected/disabled for an extended period of time, to ensure it is not interfering with Plex remote access.
Configuring port forwarding with a BGW320: Changed ISP - No Remote Access with AT&T BGW 320-500 - #3 by FordGuy61
Have only one network connection on the Plex server active. If the PC also has a Wi-Fi interface, then disable it.
Ensure the Ethernet port is Private, not Public. Settings → Network & Internet → Properties.
Ensure the PC cannot power down the Ethernet port to save power.
- In the Taskbar search box, enter
Network Connectionsto bring up the control panel. - Right click on the Ethernet interface & choose Properties.
- In the Properties window choose Configure → Power Management
- Uncheck “Allow the computer to turn off…” and OK to save.
Use Tautulli or a service such as Uptime Robot (free) to notify you when remote access is not available (have Uptime Robot monitor the public IP address & port of your Plex server).