I realize that this topic was discussed previously, but it was automatically closed, so I have to open a new thread.
I am having the exact problem described here: Roku client misaligned UI elements and I went through the exact same troubleshooting steps and also finally decided to do a factory reset - which worked. Until today.
One thing that I found that wasn’t in the original post was that restarting the roku via the roku menu almost always CAUSED the problem to happen.
So, I think that Roku may have restarted to install an update and that’s why I’m seeing the problem now. Doing a factory reset isn’t the end of the world, but this is clearly an issue - though possibly just with one specific model of Roku Ultra.
I am happy to post more information if that will be helpful, but my screen shots will look exactly like the ones posted by @spazrobot