I am having the same problem.
Current Plex version Version 1.21.4.4079-1b7748a7b
Trying to add a folder on a NAS - “Your changes could not be saved.”
Tried to add new directory on the same internal drive that the other libraries are on - “Your changes could not be saved.”
Followed the instructions to rebuild the data bases - repeated the above and still “Your changes could not be saved.”
Rebooted the Plex server (Windows Box) - same problem
Turned off IPV 6 - same problem
Cleaned out the temp folder for the user that logs into and runs the Plex server - same issue
Tried Firefox, Chrome, Edge and Safari - same issue
Tried Chrome and Edge (new Edge) on the Plex server its self - same issue
Checked the rights to the folder - no issues - same issue
Tried it from the app instead of a browser - same issue
Tried removing the current folder and then added the new folder - same issue
I use Windows Security for Anti-Virus - turned off real-time protection - same issue
Turned off UAC - same issue
At this point I believe I have tried everything, but no joy on adding a folder. My goal is actually to move data to a NAS for more storage, but that is on hold due to all of the above. I am confident the NAS is fine, and since I cannot even add a folder that is on the same drive I think the technical term here is… Plex server is busted!
HELP!!