Plex Media Server 1.22.1.4228 Web Client 4.53.0 breaks playback

Server Version#: 1.22.1.4228 (Debian 10.9)
Player Version#: 4.53.0

This is a private server, mostly family movies and photos, no remote access enabled.
Web Client appears to be trying to hit localhost for playback but the plexmediaserver is running elsewhere on the local network.

Web Client shows the Media library is available, search is functional, but hitting “Play” on any media does nothing.

Downgrading to 1.22.0.4163 (previous version I had installed) restored web client playback functionality.

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