Server Version#: 1.18.1.2019
Player Version#: 4.12.2
As with the previous update (1973), hardware transcoding (with a GTX1060) immediately causes PMS to crash on Windows 10.
Logs attached.
Plex Media Server Logs_2019-11-12_14-37-01.zip (1.5 MB)
Edit to add: Rolling back to 1.18.0.1944 fixes the issue.